Parmelee is a surname. Notable people with the surname include:
Arthur H. Parmelee (1883–1961), U.S. physician and football coachAshbel P. Fitch (P. for Parmelee; 1848–1904), U.S. Representative from the state of New YorkCharles Henry Parmelee (1855–1914), Canadian publisher and politicianChris Parmelee (born 1988), U.S. baseball playerEdward Parmelee Smith (1827–1876), U.S. religious leader, educator, co-founder of Fisk UniversityHenry S. Parmelee (c.1846–1902), U.S. inventor, piano manufacturer, and streetcar/tram company presidentHorace Parmelee (1889–1957), U.S. talent manager and concert promoterIrene E. Parmelee (1847–1934), U.S. portrait artistJames Parmelee (fl. 1886), U.S. financierOlive Miriam Buchholz Parmelee (1913–), U.S. painterPhilip Orin Parmelee (1887–1912), U.S. aviation pioneerRoy Parmelee (1907–1981), U.S. baseball player