Pappalysin 1

Pappalysin-1 (EC 3.4.24.79, insulin-like growth factor binding protein-4 protease, pregnancy-associated plasma protein-A) is an enzyme. This enzyme catalyses the following chemical reaction

Cleavage of the Met¹³⁵-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser1⁴³-Lys bond in IGFBP-5

This enzyme belongs to the peptidase family M43.