Papandreou (Greek: Παπανδρέου) is a Greek surname. It is the surname of:
Andreas Papandreou (1919–1996), Greek economist and politician and Prime Minister of Greece.
Dimitrios Papandreou (1891–1949), Archbishop Damaskinos of Athens.
George Papandreou (born 1952), Greek politician and Prime Minister of Greece.
Georgios Papandreou (1888–1968), Greek politician and Prime Minister of Greece.
Georgios Papandreou (historian) (1859–1940), historian and linguist
Giorgos Papandreou (born 1969), footballer