Paolini is an Italian surname. Notable people with the surname include:
Christopher Paolini (born 1983), American fantasy and science-fiction writer
Enrico Paolini (born 1945), Italian cyclist
Gabriele Paolini (born 1974), Italian television prankster and condom advocate
Giulio Paolini (born 1940), Italian sculptor
Luca Paolini (born 1977), Italian professional road bicycle racer
Marco Paolini (born 1956), Italian stage actor
Pietro Paolini (1603–1681), Italian painter of the Baroque era
Giovanna Paolini (born 2001), Brazilian personality
