Panayiotou (Παναγιώτου; also transcribed as Panagiotou) is a surname of Greek origin.
Andreas Panayiotou (born 1966), Cypriot footballer
Emilios Panayiotou (born 1992), Cypriot footballer
Feidias Panayiotou (born 1989), Cypriot footballer
Georgios Kyriacos Panayiotou, real name of George Michael (1963–2016), English singer and songwriter
Harry Panayiotou (born 1994), Saint Kitts and Nevis footballer
Melanie Panayiotou (born 1984), Australian marathon runner
Nicos Panayiotou (born 1970), Cypriot footballer
Panayiotis Panayiotou (born 1988), Cypriot footballer
See also
Panayiotou v Sony Music Entertainment (UK) Ltd