Panayiotou (Παναγιώτου; also transcribed as Panagiotou) is a surname of Greek origin.
Andreas Panayiotou (born 1966), Cypriot footballerEmilios Panayiotou (born 1992), Cypriot footballerFeidias Panayiotou (born 1989), Cypriot footballerGeorgios Kyriacos Panayiotou, real name of George Michael (1963–2016), English singer and songwriterHarry Panayiotou (born 1994), Saint Kitts and Nevis footballerMelanie Panayiotou (born 1984), Australian marathon runnerNicos Panayiotou (born 1970), Cypriot footballerPanayiotis Panayiotou (born 1988), Cypriot footballerSee alsoPanayiotou v Sony Music Entertainment (UK) Ltd