Palladino is an Italian surname. Notable people with the surname include:
Adriano Palladino (1610–1680), Italian painter of the Baroque era
Aleksa Palladino (born 1980), American actress and singer
Amy Sherman-Palladino, American television writer and producer
Daniel Palladino, American television writer and producer
Eddie Palladino, American basketball announcer for the Boston Celtics
Erik Palladino (born 1968), American television actor
Eusapia Palladino (1854–1918), Italian spiritualist and medium
Jack Palladino, American private investigator hired by the Bill Clinton presidential election committee
Leandro Palladino (born 1976), retired Argentine-Italian professional basketball player
Marco Palladino (born 1988), Serbian-Italian inventor, software developer and internet entrepreneur
Pino Palladino (born 1957), Welsh rock and rhythm & blues bass player
Raffaele Palladino (born 1984), Italian professional football player
Robert Palladino (1932–2016), American academic
Tony Palladino (born 1983), English professional cricketer
