Palladino is an Italian surname. Notable people with the surname include:
Adriano Palladino (1610–1680), Italian painter of the Baroque eraAleksa Palladino (born 1980), American actress and singerAmy Sherman-Palladino, American television writer and producerDaniel Palladino, American television writer and producerEddie Palladino, American basketball announcer for the Boston CelticsErik Palladino (born 1968), American television actorEusapia Palladino (1854–1918), Italian spiritualist and mediumJack Palladino, American private investigator hired by the Bill Clinton presidential election committeeLeandro Palladino (born 1976), retired Argentine-Italian professional basketball playerMarco Palladino (born 1988), Serbian-Italian inventor, software developer and internet entrepreneurPino Palladino (born 1957), Welsh rock and rhythm & blues bass playerRaffaele Palladino (born 1984), Italian professional football playerRobert Palladino (1932–2016), American academicTony Palladino (born 1983), English professional cricketer