Palfrey is a surname. Notable people with the surname include:
Daf Palfrey (born 1973), Welsh television, film and video director, producer and writerDeborah Jeane Palfrey (1956–2008), operated an escort agency in Washington, D.C., convicted in 2008 of racketeering, money laundering, etc.Francis Winthrop Palfrey (1831–1889), American historian, born in Boston, Massachusetts son of J. G. PalfreyJohn G. Palfrey (1796–1881), American clergyman and historian who served as a U.S. Representative from MassachusettsJohn Palfrey (born 1972), faculty co-director of the Berkman Center for Internet & Society at Harvard Law SchoolJudith Palfrey (born 1943), the T. Berry Brazelton Professor of Pediatrics at Harvard Medical SchoolLisa Palfrey, Welsh television actress best known for playing the character of Rhiannedd Frost in the Welsh soap Pobol y CwmSarah Palfrey Cooke (1912–1996), female tennis player from the United StatesSean Palfrey, Welsh professional darts player who currently plays in the Professional Darts CorporationSimon Palfrey, English Scholar at Oxford University and a Fellow in English at Brasenose College, Oxford UniversityStephen Palfrey Webb (1804–1879), 3rd & 12th Mayor of Salem, Massachusetts (1842–1845, 1860–1862) and 6th Mayor of San Francisco (1854–1855)Thomas Palfrey, currently (as of 2007) the Flintridge Professor of Economics and Political Science at the California Institute of TechnologyWilliam Palfrey (1741–1780), American Patriot born in Boston, MassachusettsYolande Palfrey (1957–2011), British actress