Pakhomov (Russian: Пахо́мов) is a Russian surname. The female form is Pakhomova (Russian: Пахо́мова). The surname came from Pakhom (Russian: Пахо́м), a Russian adaptation of the Coptic-Greek name Παχώμιος. Notable people with the surname include:
Alexei Pakhomov (1900–1973), Russian painter
Anatoly Pakhomov (born 1960), Russian politician
Anton Pakhomov (born 1987), Russian football player
Boris Pakhomov (1931–2005), Soviet pentathlete
Daniil Pakhomov (born 1998), Russian swimmer
Dmitri Pakhomov (born 1994), Russian football player
Leonid Pakhomov (born 1943), Russian football manager
Lyudmila Pakhomova (1946–1986), Soviet ice dancer and the 1976 Olympic champion
Nikolay Pakhomov (1893−1938), Soviet government official
Yevgeni Pakhomov (1880–1965), Russian numismatist