Species Human Entrez 9536 | Human Mouse Ensembl ENSG00000148344 | |
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Aliases PTGES, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1, prostaglandin E synthase External IDs MGI: 1927593 HomoloGene: 3587 GeneCards: PTGES | ||
Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.
Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.
References
PTGES Wikipedia(Text) CC BY-SA