Species Human Entrez 23368 | Human Mouse Ensembl ENSG00000088808 | |
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Aliases PPP1R13B, ASPP1, p53BP2-like, p85, protein phosphatase 1 regulatory subunit 13B External IDs MGI: 1336199 HomoloGene: 9090 GeneCards: PPP1R13B | ||
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
References
PPP1R13B Wikipedia(Text) CC BY-SA