Harman Patil (Editor)

POP1 (gene)

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Covid-19
Aliases  POP1
Human  Mouse
Ensembl  ENSG00000104356
Species  Human
Entrez  10940
POP1 (gene)
External IDs  MGI: 1914974 HomoloGene: 41000 GeneCards: POP1

Ribonucleases P/MRP protein subunit POP1 is a protein that in humans is encoded by the POP1 gene.

Contents

Function

POP1 is a protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. This protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing.

Clinical significance

POP1 is also an autoantigen in patients suffering from connective tissue diseases. Mutations in the POP1 gene result in severe anauxetic dysplasia.

Interactions

POP1 (gene) has been shown to interact with POP4.

References

POP1 (gene) Wikipedia


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