Species Human Entrez 5378 | Human Mouse Ensembl ENSG00000064933 | |
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Aliases PMS1, HNPCC3, PMSL1, hMLH2, PMS1 homolog 1, mismatch repair system component External IDs MGI: 1202302 HomoloGene: 449 GeneCards: PMS1 | ||
PMS1 protein homolog 1 is a protein that in humans is encoded by the PMS1 gene.
Function
The protein encoded by this gene was identified by its homology to a yeast protein involved in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch repair protein, and some cases of hereditary nonpolyposis colorectal cancer have been found to have mutations in this gene.
References
PMS1 Wikipedia(Text) CC BY-SA