Entrez 5362 | Ensembl ENSG00000076356 | |
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External IDs MGI: 107684 HomoloGene: 56427 GeneCards: PLXNA2 |
Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.
In some studies, the PLXNA2 gene is associated with schizophrenia. and anxiety.
References
PLXNA2 Wikipedia(Text) CC BY-SA