Species Human Entrez 51196 | Human Mouse Ensembl ENSG00000138193 | |
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Aliases PLCE1, NPHS3, PLCE, PPLC, phospholipase C epsilon 1 External IDs MGI: 1921305 HomoloGene: 9478 GeneCards: PLCE1 | ||
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 is an enzyme that in humans is encoded by the PLCE1 gene.
Function
PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM]
References
PLCE1 Wikipedia(Text) CC BY-SA