Aliases PLCB3 Ensembl ENSG00000149782 | Entrez 5331 | |
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External IDs MGI: 104778 HomoloGene: 47960 GeneCards: PLCB3 |
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.
The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.
Interactions
PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.
References
PLCB3 Wikipedia(Text) CC BY-SA