Suvarna Garge (Editor)

PF 04457845

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Covid-19
ATC code  None
ChemSpider  26390839
ChEMBL  CHEMBL1651534
PubChem CID  24771824
UNII  H4C81M8YYW
Molar mass  455.432 g/mol
PF-04457845 jpetaspetjournalsorgcontentjpet3381114F2l
Legal status  US: Investigational New Drug

PF-04457845 is a potent and exquisitely selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 7.2nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.

It has been well tolerated in human trials even at high dose ranges with no evidence for cognitive dysfunction, and has completed Phase II clinical trials for the treatment of osteoarthritis, but was found to be ineffective.

References

PF-04457845 Wikipedia


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