ATC code None ChemSpider 26390839 ChEMBL CHEMBL1651534 | PubChem CID 24771824 UNII H4C81M8YYW Molar mass 455.432 g/mol | |
 | ||
Legal status US: Investigational New Drug | ||
PF-04457845 is a potent and exquisitely selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 7.2nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.
It has been well tolerated in human trials even at high dose ranges with no evidence for cognitive dysfunction, and has completed Phase II clinical trials for the treatment of osteoarthritis, but was found to be ineffective.
References
PF-04457845 Wikipedia(Text) CC BY-SA