Puneet Varma (Editor)

PF 00446687

Updated on
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Covid-19
PubChem CID  11328898
Formula  C28H36F2N2O2
3D model (Jmol)  Interactive image
ChemSpider  24669573
Molar mass  470.593
PF-00446687

PF-00446687 is a drug developed by Pfizer for the treatment of erectile dysfunction, which is a non-peptide agonist selective for the melanocortin receptor subtype MC4. It was found to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective. While it is unclear whether PF-00446687 itself will be potent and effective enough to be developed for medical use, it has demonstrated that selectively targeting the MC4 subtype can produce similar aphrodisiac effects to older non-selective peptide-based melanocortin receptor agonists like melanotan II and bremelanotide, without the side effects caused by action at the other melanocortin receptor subtypes.

References

PF-00446687 Wikipedia


Similar Topics
Love in the Time of Civil War
Kit Mueller
Kaja Rogulj
Topics
 
B
i
Link
H2
L