Entrez 50940 | Ensembl ENSG00000128655 | |
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Aliases PDE11A, PPNAD2, phosphodiesterase 11A External IDs MGI: 3036251 HomoloGene: 56763 GeneCards: PDE11A |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Inhibitors
References
PDE11A Wikipedia(Text) CC BY-SA