Harman Patil (Editor)

P21 activated kinases

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
P21-activated kinases mcbasmorgcontent313386F1largejpg

Medical vocabulary what does p21 activated kinases mean


p21 activated kinases (PAKs) are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.

Members include:

  • PAK1, regulating cell motility and morphology
  • PAK2, possibly playing a role in apoptosis
  • PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity
  • PAK4, a mediator of filopodia formation
  • PAK5, a mediator of filopodia formation
  • PAK6, involved in cytoskeleton rearrangement

    • References

    P21-activated kinases Wikipedia
    (Text) CC BY-SA