Pálffy or Palffy is a Hungarian surname which means "son of Pál". Notable people with the surname include:
Žigmund Pálffy (born 1972), Slovak ice hockey player
David Palffy (born 1969), Canadian actor of Hungarian extraction
Lipót Pálffy de Erdőd (1764–1825), Major General
Ferdinand Palffy von Erdöd (1774–1840), mining engineer in the Austrian Empire and Vienna Theatre manager
Fidél Pálffy (1895–1946), Hungarian nobleman who was a leading supporter of Nazism in Hungary
János Pálffy (1664–1751), Hungarian noble, Imperial Field marshal and Palatine of Hungary