Oxidative deamination is a form of deamination that generates oxoacids in the liver. This takes place in liver and kidney. The purpose of oxidative deamination is to provide NH3 for urea synthesis and alpha-keto acids for a variety of reactions, including energy generation.
The presence of nitrous acid can cause transition mutations, by converting cytosine to uracil. Oxidative deamination occurs primarily in the liver and kidneys.
In urea cycle
Glutamate is the only amino acid that undergoes rapid oxidative deamination by using glutamate dehydrogenase, which uses NAD or NADP as a coenzyme. This process leads to two distinct toxic compounds:
References
Oxidative deamination Wikipedia(Text) CC BY-SA