Oxaloglycolate reductase (decarboxylating)

In enzymology, an oxaloglycolate reductase (decarboxylating) (EC 1.1.1.92) is an enzyme that catalyzes the chemical reaction

D-glycerate + NAD(P)⁺ + CO₂ ⇌ 2-hydroxy-3-oxosuccinate + NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are D-glycerate, NAD⁺, NADP⁺, and CO₂, whereas its 4 products are 2-hydroxy-3-oxosuccinate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-glycerate:NAD(P)⁺ oxidoreductase (carboxylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.