Owusu is both an Akan surname and an Akan given name. The name is originally from the Akan people of Ghana. Owusu is one of the most common Akan surnames or Akan given names in Ghana. However, it is a real name; thus, there are both male and female versions. (male: "OWUSU" and female: "OWUSUA") which means "Strong Willed and Determined" in Akan language. Notable people with the name include:
Akwasi Owusu-Ansah (born 1988), American football safety and wide receiver
Andrew Owusu (born 1972), Ghanaian athlete who competes in the triple jump
Basty Owusu Kyeremateng (born 1987), Italian footballer
Belinda Owusu (born 1989), British actress
Benjamin Owusu (1989–2010), Ghanaian footballer
Chris Owusu (born 1990), American football player
Collins Owusu, contestant on Deutschland sucht den Superstar (season 5)
Daniel Owusu (born 1989), Ghanaian footballer
David Owusu, English footballer
Edmund Owusu-Ansah (born 1983), Ghanaian footballer
Ernest Owusu-Poku, former Inspector General of Police of the Ghana Police Service
Felix Owusu-Adjapong (born 1944), Ghanaian politician
Hackman Owusu-Agyeman (born 1941), Ghanaian member of parliament
Joshua Owusu (born 1948), retired Olympic track and field athlete from Ghana
Julian Owusu-Bekoe (born 1989), English-born football player
Lloyd Owusu (born 1976), professional footballer
Mercy Adoma Owusu-Nimoh (1936–2011), children's writer, recipient of a Noma Award honourable mention
Michael Owusu, British TV Producer and Gospel Music & Media Specialist
Monica Owusu-Breen, American television producer and screenwriter
Nana Owusu-Nsiah, police officer and diplomat
Obed Owusu (born 1990), Ghanaian international footballer
Owusu Afriyie (born 1980), Ghanaian former professional footballer
Owusu Ampomah (born 1985), Ghanaian footballer
Owusu Benson (born 1977), Ghanaian football player
Owusu Hayford (born 1981), former professional footballer from Ghana
Owusu-Ankomah (born 1956), contemporary Ghanaian/German painter
Owusu-Ansah Kontoh (born 1992), Ghanaian football midfielder
Papa Owusu-Ankomah (born 1958), Ghanaian politician
Princeton Owusu-Ansah (born 1976), retired Ghanaian football midfielder
Quincy Owusu-Abeyie (born 1986), Ghanaian international footballer
Victor Owusu (1923–2000), former Ghanaian politician and lawyer
William Owusu (born 1989), Ghanaian footballer
William Owusu (born 1991) (born 1991), Ghanaian footballer