Osei is both an Ashanti surname and an Ashanti given name. Notable people with the Ashanti name include:
Surname:
Emmanuel Osei (born 1981), Ghanaian association football player
Emmanuel Osei Kuffour (born 1976), Ghanaian association football player
Kennedy Osei (born 1966), Ghanaian middle distance runner
Kevin Osei (born 1991), French-born Ghanaian association football player
Ransford Osei (born 1990), Ghanaian professional association football player
Mikki Osei Berko, Ghanaian actor
Nana Osei Bonsu II (born 1939), Regent of the Ashanti Kingdom
Otumfuo Nana Osei Tutu II (born 1950), Asantehene
Given name:
Osei Bonsu (died 1824), Asantehene
Osei Kofi Tutu I (died 1717), founder of the Ashanti Confederacy
Osei Kwadwo, Ashanti king
Osei Kwame Panyin, Asantehene
Osei Sankofa (born 1985), English association football player
Osei Parris (born 2000), Dutch student