Orsini is a surname of Italian origin, ultimately derived from Latin ursinus ("bearlike") and originating as an epithet or sobriquet describing the name-bearer's purported strength. Notable people with the surname include the following:
Orsini family, Italian noble family
Alessandro Orsini, sociologist
Alessandro Orsini (1592–1626), cardinal
Angel Orsini, American professional wrestler and bodybuilder
Clarice Orsini (1453–1488), mother of Pope Leo X
Felice Orsini (1819–1858), Italian revolutionary who attempted to assassinate Napoléon III
Frank Orsini (1938-2016), Catholic Philosopher, AA Convention Speaker, Actor
Fulvio Orsini (1529–1600), Italian historian
Giordano Orsini (died 1438), 15th-century Italian cardinal
Giordano Orsini (died 1173), Catholic prelate
Giorgio Orsini (1410–1475), architect and sculptor
Pope Nicholas III, born Giovanni Gaetano Orsini
Giovanni Gaetano Orsini (cardinal) (c.1285–1335), nephew of Pope Nicholas III
John II Orsini (died 1335), known as the Despot of Epirus
Latino Orsini (1411–1477), Catholic cardinal
Latino Orsini (c. 1530–1580), military architect and diplomat
Latino Malabranca Orsini (d. 1294), Catholic prelate
Marina Orsini (born 1967), Canadian actress
Matteo Orsini (d. 1340), Catholic prelate
Michael Orsini (born 1962) Catholic Ethics and Morality Teacher
Napoleone Orsini (1420–1480), condottiero and pappal commander
Paolo Giordano Orsini (disambiguation)
Pope Benedict XIII, born Pietro Francisco Orsini
Rinaldo Orsini (d. 1450), Lord of Piombino
Umberto Orsini (born 1934), stage, television and film actor
Valentino Orsini (1927–2001), film director
Virginio Orsini (1434–1497), Lord of Bracciano
