Orsini is a surname of Italian origin, ultimately derived from Latin ursinus ("bearlike") and originating as an epithet or sobriquet describing the name-bearer's purported strength. Notable people with the surname include the following:
Orsini family, Italian noble familyAlessandro Orsini, sociologistAlessandro Orsini (1592–1626), cardinalAngel Orsini, American professional wrestler and bodybuilderClarice Orsini (1453–1488), mother of Pope Leo XFelice Orsini (1819–1858), Italian revolutionary who attempted to assassinate Napoléon IIIFrank Orsini (1938-2016), Catholic Philosopher, AA Convention Speaker, ActorFulvio Orsini (1529–1600), Italian historianGiordano Orsini (died 1438), 15th-century Italian cardinalGiordano Orsini (died 1173), Catholic prelateGiorgio Orsini (1410–1475), architect and sculptorPope Nicholas III, born Giovanni Gaetano OrsiniGiovanni Gaetano Orsini (cardinal) (c.1285–1335), nephew of Pope Nicholas IIIJohn II Orsini (died 1335), known as the Despot of EpirusLatino Orsini (1411–1477), Catholic cardinalLatino Orsini (c. 1530–1580), military architect and diplomatLatino Malabranca Orsini (d. 1294), Catholic prelateMarina Orsini (born 1967), Canadian actressMatteo Orsini (d. 1340), Catholic prelateMichael Orsini (born 1962) Catholic Ethics and Morality TeacherNapoleone Orsini (1420–1480), condottiero and pappal commanderPaolo Giordano Orsini (disambiguation)Pope Benedict XIII, born Pietro Francisco OrsiniRinaldo Orsini (d. 1450), Lord of PiombinoUmberto Orsini (born 1934), stage, television and film actorValentino Orsini (1927–2001), film directorVirginio Orsini (1434–1497), Lord of Bracciano