Orozco is of Spanish/Basque origin. Notable people with the surname include:
Ana María Orozco (born 1973), Colombian television actress
Andrés Orozco (born 1979), Colombian football defender
Antonio Orozco (born 1972), Spanish singer-songwriter
Ashley Orozco (born 2003), Instagram famous (aashley.orozco)
Aurora Estrada Orozco (1918–2011), Mexican American community leader
Caleb Orozco, LGBT activist in Belize
Daniel Orozco, an American writer of fiction
Danilo Orozco (1944–2013), Cuban musicologist
Edwin Orozco (born 1982), Colombian road cyclist
Esther Orozco (born 1945), Mexican biologist and researcher
Gabriel Orozco (born 1962), Mexican postminimalist artist
Germán Orozco (born 1976), Argentine field hockey defender
John Orozco (born 1992), American gymnast
Jonathan Orozco, Mexican football player
José Clemente Orozco (1883–1949), Mexican painter
Lisseth Orozco (born 1986), Colombian judoka
Michael Orozco Fiscal (born 1986), American soccer player
Olga Orozco (1920–1999), Argentine poet
Pascual Orozco(sometimes spelled Oroszco) (1882–1915), Mexican revolutionary leader
Rafael Orozco (disambiguation), multiple people
Soledad Orozco de Avila Camacho, first lady of Mexico (1940–1946); her husband was Manuel Avila Camacho.
Verónica Orozco, Colombian actress and singer, Ana María Orozco sister
Juan Orozco, Spanish luthier and guitar impresario, famous guitar shop in New York (1970s to 1990s)