NASA's Origins program is a decades-long study addressing the origins of the universe, various astronomical bodies, and life. The Origins program was started in the 1990s.
So far, it consists of the following missions:
ground based
Keck telescopes*
Large Binocular Telescope Interferometer*
Keck Interferometer*
airborne
Stratospheric Observatory for Infrared Astronomy (SOFIA)*
space based
Hubble Space Telescope (HST)* e
Far Ultraviolet Spectroscopic Explorer (FUSE) - completed
Spitzer Space Telescope (SST)*
Kepler Space Observatory*
Space Interferometry Mission (SIM) - cancelled
Terrestrial Planet Finder (TPF) - cancelled
James Webb Space Telescope (JWST) - in development
Single Aperture Far Infrared Observatory (SAFIR)
Large UV/Optical Telescope
Life Finder
Planet Imager
Missions marked with * are operational.