Oppenheim is a German surname. Notable people with the surname include:
A. Leo Oppenheim (1904–1974), AssyriologistAlan V. Oppenheim (born 1937), professor of Electrical Engineering at MIT and authorAlexander Oppenheim (1903-1997), British mathematician and university administratorAlfred Freiherr von Oppenheim (1934–2005), associate of Sal. Oppenheim bankAlfred Oppenheim (1878-1943), German chemist and manufacturerAvrohom Chaim Oppenheim (1796?–1824?), Rabbi at Péczel, HungaryDavid Oppenheim (clarinetist) (1922–2007), an American clarinetist and classical music and television producerDavid Oppenheim (poker player), American professional poker playerDavid Oppenheim (rabbi) (1664–1736), a chief rabbi of PragueDennis Oppenheim (1938–2011), American conceptual artist, performance artist, sculptor, and photographerE. Phillips Oppenheim (1866–1946), English novelistHeinrich Bernhard Oppenheim (1819–1880), German jurist, politician, and philosopherHermann Oppenheim (1858–1919), German neurologistJames Oppenheim (1882–1932), American poet, author, and editorJill Arlyn Oppenheim (born 1940), American actress better known as Jill St. JohnL. F. L. Oppenheim (1858–1919), German juristMatt Oppenheim (born 1967), former Senior VP of Legal and Business Affairs for the RIAAMax von Oppenheim (1860–1946), German diplomat and archaeologistMeret Oppenheim (1913–1985), Swiss artist and lyricistMoritz Daniel Oppenheim (1800–1882), German painterSally Oppenheim (born 1930), shortened name for Sally Oppenheim-Barnes, Baroness Oppenheim-Barnes, former UK member of ParliamentSalomon Oppenheim, Jr. (1772–1828), founder of the Sal. Oppenheim bankSamuel Oppenheim (1857–1928), Austrian astronomer