Opoku is both an Ashanti given name and an Ashanti surname. Notable people with the Ashanti name include:
Colleen Opoku Amuaben (born 1960), general superintendentDorcas Opoku Dakwa (or Abrewa Nana) (born 1980), Ghanaian singer, songwriter and dancerEric Opoku-Agyemang (or Eric Opoku) (born 1991), Ghanaian footballerJonathan Opoku (born 1990), Dutch professional footballerJordan Opoku (born 1983), Ghanaian footballerJoshua Drew Opoku Okoampa (or Joshua Okoampa) (born 1984), American soccer playerJoshua Otto Opoku (or Joshua Otto) (born 1990), Ghanaian footballerNaana Jane Opoku-Agyemang (born 1951), Ghanaian academicNana Opoku Agyemang-Prempeh (or Agyemang Opoku) (born 1989), Ghanaian footballerPrince Opoku Bismark Polley Sampene (or Prince Polley) (born 1969), Ghanaian footballerSamuel Opoku Nti known as Opoku Nti (born 1961), Ghanaian footballerStanley Opoku Aborah (or Stanley Aborah) (born 1987), Ghanaian-Belgian professional footballerRichard Opoku Osei (or Richard Osei) (born 1985), Ghanaian footballerGiven nameOpoku Ware I (1700–1750), AsanteheneOpoku Ware II (1919–1999), fifteenth King of the Empire of AshantiOpoku Afriyie, Ghanaian footballer and manager