Opie is both a surname and a given name. Notable people with the name include:
Alan Opie, (born 1945), baritone singer
Amelia Opie (1769-1853), English author - wife of John Opie
Catherine Opie, (born 1961), American artist and photographer
Eugene Lindsay Opie (1873-1971), American pathologist
Iona Opie, (born 1923), specialist in children's literature, and the customs of schoolchildren - wife of Peter Opie
John Opie, (1761-1807), Cornish historical and portrait painter - husband of Amelia Opie
Julian Opie, British artist, famed for his use of vector-based reproductions
Lisa Opie, (born 1963), English squash player
Opie Ortiz, artist specializing in tattoos, pop art and murals
Opie Cates, (1909-1987), American clarinet player
Peter Opie, (1918-1982) English specialist in children's literature, and the customs of schoolchildren - husband of Iona Opie
Redvers Opie (1900-1984) British economist
Robert Opie, British item collector and director of the Museum of Brands, Packaging and Advertising