Kalpana Kalpana (Editor)

Omega atracotoxin

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Covid-19
Symbol  Omega-toxin
InterPro  IPR009415
SUPERFAMILY  1hvw
Pfam  PF06357
SCOP  1hvw
Pfam  structures

Omega-atracotoxin is an insect-specific neurotoxin produced by the Blue Mountains funnel-web spider. Its phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.

References

Omega-atracotoxin Wikipedia


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