Ōkubo (大久保), also Ohkubo, is a Japanese surname. Notable people with the surname include:
Ōkubo clan
Ōkubo Tadayo (1532–1594), Japanese daimyo of the Sengoku period
Ōkubo Tadasuke (1537–1613), Japanese daimyo of the Sengoku and Edo periods
Ōkubo Nagayasu (1545–1613), Japanese samurai of the Edo period
Ōkubo Tadachika (1553–1628), Japanese daimyo of the Sengoku and Edo periods
Ōkubo Tadataka (1560–1639), Japanese samurai of the Sengoku and Edo periods
Ōkubo Tadazane (1778–1837), Japanese daimyo of the late Edo period
Ōkubo Toshimichi (1830–1878), Japanese samurai and later leader of the Meiji restoration
Contemporary
Atsushi Ōkubo, Japanese manga author
Hiroshi Okubo, Japanese video game music composer
James K. Okubo, American Medal of Honor recipient
Ōkubo Haruno, Japanese general
Hideo Ohkubo, Japanese businessman
Kaoru Okubo, Japanese anime music composer
Kiyoshi Ōkubo, Japanese serial killer
Koroku Ōkubo, Japanese photographer
Mariko Okubo, Japanese actress
Miné Okubo, American artist
Tsutomu Okubo, Japanese politician
Susumu Ōkubo, who proposed the Gell-Mann–Okubo mass formula
Yukishige Okubo, Japanese politician
Footballers
Goshi Okubo, Japanese footballer
Makoto Okubo, Japanese footballer
Takuo Ōkubo, Japanese footballer
Tetsuya Ōkubo, Japanese footballer
Yoshito Ōkubo, Japanese footballer
Yuki Okubo, Japanese footballer
