| Thinobadistes, Nematherium, Hapalops, Catonyx, Pronothrotherium|
Octodontotherium is an extinct genus of ground sloth of the family Mylodontidae, endemic to South America during the Oligocene-Miocene. It lived from 29—21 mya, existing for approximately 8 million years.
Fossil distribution is exclusive to Santa Cruz Province, Argentina.
Octodontotherium was named by Ameghino (1894). It was assigned to Mylodontidae by Carroll (1988); and to Mylodontinae by Gaudin (1995).