Species Human Entrez 4940 | Human Mouse Ensembl ENSG00000111331 | |
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Aliases OAS3, p100, p100OAS, 2'-5'-oligoadenylate synthetase 3 External IDs MGI: 2180850 HomoloGene: 4510 GeneCards: OAS3 | ||
2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligos activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.
References
OAS3 Wikipedia(Text) CC BY-SA