O'Shea /oʊˈʃeɪ/ is a surname (an anglicized form of the Irish patronymic name Ó Séaghdha or Ó Sé), originating in the Kingdom of Corcu Duibne in County Kerry, and could refer to:
Alicia O'Shea Petersen (1862-1923), Australian suffragist
Brian O'Shea (politician) (born 1944), Irish politician
Brian O'Shea (boxer), American boxer
Clarrie O'Shea (1906-1988), Australian labor union secretary
Franc O'Shea, Swazi musician
James O'Shea and John O'Shea, Victorian stone carvers associated with John Ruskin
Jack O'Shea (born 1957), All-Ireland winning Gaelic footballer from County Kerry
Jack O'Shea's, award winning Irish butcher
Jay O'Shea (born 1988), Irish footballer
John O'Shea (born 1981), Irish international footballer who has won the Premier League, the FA Cup and the UEFA Champions League
John O'Shea (director) (1920-2001), New Zealand film director
John O'Shea (humanitarian) (born 1944), Irish founder of GOAL, international humanitarian organization based in Ireland
John Augustus O'Shea (1839–1905), Irish soldier, journalist, and writer
Katherine O'Shea (1846-1921), English wife of Irish politician, Charles Stewart Parnell
Kelvin O'Shea (born 1933), Australian rugby league footballer
Kevin O'Shea (July 10, 1925 – February 21, 2003) was an All-American college basketball player who later played professionally. He was born in San Francisco, California
Mark O'Shea (herpetologist) (born 1956), English herpetologist
Mark O'Shea (musician) (born 16 February 1977), Australian singer-songwriter
Michael O'Shea (Canadian football) (born 1970), Canadian football player
Milo O'Shea (1926-2013), Irish actor
Natalia O'Shea (born 1976), Russian linguist and musician
Rick O'Shea (born 1973), Irish radio DJ
Shayne O'Shea (born 1956), Irish American Wiccan Democrat and founder of the Temple of the Triple Goddess
Steve O'Shea, New Zealand is marine biologist and environmentalist
Tessie O'Shea (1913-1995), Welsh entertainer and actress
Timothy O'Shea (born 1949), vice-chancellor and principal of the University of Edinburgh
Tony O'Shea (born 1961), English darts player
William O'Shea (1840-1905), Irish soldier and Member of Parliament
Much less commonly, O'Shea might be used as a first name:
O'Shea Jackson (born 1969), rapper, commonly known as Ice Cube
O'Shea Jackson, Jr. (born 1991), his son, rapper and actor