O'Malley is an Irish surname (Anglicisation of "Ó Máille"). Notable persons with that name include:
Bryan Lee O'Malley (born 1979), comic book creator
Daragh O'Malley (born 1954), Irish actor
Desmond O'Malley (born 1939), Irish politician
Donogh O'Malley (1921–1968), Irish Fianna Fáil politician
Edward R. O'Malley (1863–1935), American lawyer and politician
Edwin O'Malley (1881–1955), Commissioner of Public Markets for New York City
Ernie O'Malley (1897–1957), Irish Republican Army officer
Fiona O'Malley (born 1968), Irish Progressive Democrat politician
Grace O'Malley (c.1530–c.1603), Irish noblewoman and chieftainess
Joe O'Malley (1932–2015), American football player
John O'Malley (1878-1940), American politician
John F. O'Malley, American architect
John J. O'Malley, American architect
J. Pat O'Malley (1904–1985), English singer and actor
Katie O'Malley (born 1962), Maryland state judge
King O'Malley (1858–1953), Australian politician
Martin O'Malley (born 1963), American politician
Martin O'Malley (journalist) (born 1939), Canadian journalist
Mary O'Malley (disambiguation), various including
Mary O'Malley (poet) (born 1954), Irish poet
Mary O'Malley (playwright) (born 1941), English playwright
Mary O'Malley (director) (1918–2006), Irish director
Matthew V. O'Malley (1878–1931), American politician
Mick O'Malley (born 1972), Australian boxer of the 1990s and 2000s
Mike O'Malley (born 1969), American actor
Nick O'Malley (born 1985), indie-rock musician
Sir Owen O'Malley (1887–1974), British diplomat
Patrick O'Malley (disambiguation) or Pat O'Malley, various including
Patrick O'Malley (American politician) (born 1950), former Illinois State Senator
Patrick O'Malley (Irish politician) (born 1943), Irish Progressive Democrats politician
Padraig O'Malley (born 1942), Irish-American academic
Peter O'Malley (born 1937), former owner of the Los Angeles Dodgers baseball team
Robert E. O'Malley (born 1943), Medal of Honor recipient
Rory O'Malley (born 1980), Broadway actor
Ryan O'Malley (born 1980), American baseball player
Ryan O'Malley (American football) (born 1993), American football player
Sean O'Malley (born 1944), Roman Catholic Cardinal
Stephen O'Malley (born 1974), American musician
Thomas O'Malley (congressman) (1903–1979), U.S. Representative from Wisconsin
Thomas J. O'Malley (1868–1936), Lieutenant Governor of Wisconsin
Tim O'Malley (born 1944), Irish politician
Tony O'Malley (1913–2003), Irish painter
Walter O'Malley (1903–1979), former owner of the Brooklyn/Los Angeles Dodgers baseball team
William O'Malley (Irish politician) (1853–1939), MP for Connemara,1906
William O'Malley (Jesuit) (born 1928), American Jesuit priest, teacher, and author
