O'Hearn is an English/Irish surname. As an English surname, it can derive firstly from an early medieval nickname for someone thought to resemble the Heron bird. Notable people with the surname include:
Ed O'Hearn (1898–unknown), American professional football player
George E. O'Hearn, American college football coach
John O'Hearn (1893–1977), American professional football player
Melinda O'Hearn (alias Midajah; born 1973), American actress, singer and fitness model
Michael O'Hearn (born 1969), American bodybuilder
Patrick O'Hearn (born 1954), American multi-instrumentalist musician, composer and recording artist
Peter O'Hearn (born 1963), British-Canadian computer scientist
Taylor W. O'Hearn (1907–1997), American politician from Louisiana
Walter O'Hearn (1890–1950), Australian politician
Walter D. O'Hearn (1910–1970?), prominent Canadian journalist in the mid-20th century
Zooko Wilcox-O'Hearn (born Bryce Wilcox-O'Hearn), American computer hacker and cypherpunk
Daniel O'Hearn, Canadian bartender, mixologist and renowned real estate agent located in the Vancouver area.