Nucleobindin 1

Updated on Jan 05, 2024

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Species Human Entrez 4924		Human Mouse Ensembl ENSG00000104805

Aliases NUCB1, CALNUC, NUC, nucleobindin 1 External IDs MGI: 97388 HomoloGene: 4507 GeneCards: NUCB1

Nucleobindin-1 (NUCB1), also known as calnuc, is a protein that in humans is encoded by the NUCB1 gene.

Structure

The human calnuc protein contains 461 amino acids and has a pI of 4.9.

The protein contains the following regions and domains:

Signal peptide

Leucine-zipper The leucine-zipper of calnuc may be responsible for its dimerization.

aa 347-389 – Nuclear localization signal

2 zinc binding sites with high affinity (K_d = 20 nM)

carboxypeptidase-like motifs : HFREXnH (aa 66) and HFTEXnH (aa 146)

2 EF-hands

Potential anchor region– 15-aa hydrophobic region at its COOH terminus that may be sufficient for membrane anchoring

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