Nrf2 internal ribosome entry site (IRES)

In molecular biology, the Ure2 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA encoding the transcription factor Nrf2. It contains a stem-loop structure upstream of a ribosome binding site. This stem loop inhibits ribosome binding and translation of Nrf2 under normal conditions, but allows translation under oxidative stress conditions.