Nobili is an Italian surname. Notable people with the surname include:
Anna Maria Nobili, Italian physicistBrian Nobili (born 1976), American photographerBruno Nobili (born 1949), Italian-Venezuelan footballer and managerDurante Nobili, 16th-century Italian painterElena Nobili (1833–1900), Italian painterJohn Nobili (1812–1856), Italian Roman Catholic priestLeopoldo Nobili (1784–1835), Italian physicistRiccardo Nobili (1859–1939), Italian painter, writer and antiquarianSimone Nobili (born 1991), Italian modelTito Oro Nobili (1882–1967), Italian politician