Nightingale is an English surname. Notable people with this surname include the following:
Nightingale Baronets, a title in the Baronetage of England
Albert Nightingale (1923–2006), English footballer
Andrea Nightingale, American classical scholar
Annie Nightingale (born 1942), British radio broadcaster
Anthony Nightingale (born 1947), Hong Kong businessman
Benedict Nightingale (born 1939), British journalist
Danny Nightingale (born 1954),British modern pentathlete
Danny Nightingale (soldier) (born 1975), British soldier
David Nightingale, English footballer
Earl Nightingale (1921–1989), American motivational speaker
Florence Nightingale (1820–1910), British pioneer of modern nursing and statistician
James Nightingale (born 1986), Papua New Guinean rugby league player
James Nightingale (footballer), English footballer
James Nightingale (cricketer) (1840–1917), English cricketer
Jared Nightingale (born 1982), American ice hockey defenceman
Jason Nightingale (born 1986), New Zealand rugby player
John Nightingale (actor) (c.1943–1980), British actor
John Nightingale (figure skater) (born 1928), American figure skater
John Nightingale (MP) for Leicester (UK Parliament constituency)
Joseph Nightingale (1775–1824), English writer and preacher
Luke Nightingale (born 1980), English footballer
Lynn Nightingale (born 1956), Canadian figure skater
Mark Nightingale (born 1967), British jazz trombonists
Mary Nightingale (born 1963), English newsreader and television presenter
Maxine Nightingale (born 1952), British soul music singer
Michael Nightingale (1922–1999), English actor
Neil Nightingale, British naturalist and television producer
Tunde Nightingale (Earnest Olatunde Thomas) (1922–1981), Nigerian singer and guitarist
Wally Nightingale (1956–1996), English guitarist of the Sex Pistols
William Nightingale (1794–1874), English Unitarian, the father of Florence Nightingale