Nieuwenhuis or Nieuwenhuys is a Dutch surname. Notable people with the surname include:
Anton Willem Nieuwenhuis (1864–1953), Dutch explorer who crossed Borneo in 1896-97Berry Nieuwenhuys (1911-1984), South African born British soccer playerConstant Nieuwenhuys (1920–2005), Dutch painterFerdinand Domela Nieuwenhuis (1846–1919), the Netherlands' first prominent socialistJacques Nieuwenhuis (born 1980), Namibian rugby playerJan Nieuwenhuys (1922–1986), Dutch painterKirk Nieuwenhuis (born 1987), American baseball playerPim Nieuwenhuis (born 1976), Dutch sailorRob Nieuwenhuys (1908–1999), Dutch writer