Nieuwenhuis or Nieuwenhuys is a Dutch surname. Notable people with the surname include:
Anton Willem Nieuwenhuis (1864–1953), Dutch explorer who crossed Borneo in 1896-97
Berry Nieuwenhuys (1911-1984), South African born British soccer player
Constant Nieuwenhuys (1920–2005), Dutch painter
Ferdinand Domela Nieuwenhuis (1846–1919), the Netherlands' first prominent socialist
Jacques Nieuwenhuis (born 1980), Namibian rugby player
Jan Nieuwenhuys (1922–1986), Dutch painter
Kirk Nieuwenhuis (born 1987), American baseball player
Pim Nieuwenhuis (born 1976), Dutch sailor
Rob Nieuwenhuys (1908–1999), Dutch writer
