Harman Patil (Editor)

Nicotine dehydrogenase

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Covid-19
EC number  1.5.99.4
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  37256-31-8
BRENDA  BRENDA entry
KEGG  KEGG entry

In enzymology, a nicotine dehydrogenase (EC 1.5.99.4) is an enzyme that catalyzes the chemical reaction

(S)-nicotine + acceptor + H2O (S)-6-hydroxynicotine + reduced acceptor

The 3 substrates of this enzyme are (S)-nicotine, acceptor, and H2O, whereas its two products are (S)-6-hydroxynicotine and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is nicotine:acceptor 6-oxidoreductase (hydroxylating). Other names in common use include nicotine oxidase, D-nicotine oxidase, nicotine:(acceptor) 6-oxidoreductase (hydroxylating), and L-nicotine oxidase. It has 2 cofactors: metal, and FMN.

References

Nicotine dehydrogenase Wikipedia


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