Nicotine blue oxidoreductase

Nicotine blue oxidoreductase (EC 1.1.1.328, nboR (gene)) is an enzyme with systematic name 3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP⁺ 11-oxidoreductase. This enzyme catalyses the following chemical reaction

3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(P)⁺ ⇌ (E)-2,2',5,5'-tetrahydroxy-6H,6'H-[3,3'-bipyridinylidene]-6,6'-dione + NAD(P)H + H⁺

This enzyme is extracted from bacterium Arthrobacter nicotinovorans.