Negroni is an Italian/Corsican surname. Notable people with the surname include:
Daniele Negroni (1995), an Italian singer and runner-up on Deutschland sucht den Superstar (season 9)
Héctor Andrés Negroni, military officer, historian, aerospace senior executive
Joe Negroni, founding member of the rock and roll group Frankie Lymon and the Teenagers
Jean Negroni, narrator in French film La Jetée
Luca Negroni (born 1964), Italian ski mountaineer
General Pascal Olivier Count de Negroni, Led the charge of Cuirassiers in the Battle of Reichshoffen during the Franco-Prussian War of 1870.
