Negrini is an Italian surname. Notable people with the surname include:
Alessandra Negrini (born 1970), Brazilian actressAntonio Negrini (1903–1994), Italian cyclistCarlo Negrini (1826–1865), Italian opera singerChiara Negrini (born 1979), Italian volleyball playerGualtiero Negrini (born 1961), American opera singerLuciano Negrini (born 1920), Italian rowerMatteo Negrini (born 1982), Italian footballerVincenzo Negrini (1804–1840), Italian opera singer