Neagle is a surname. Notable people with the surname include:
Anna Neagle, DBE (1904–1986), born Florence Marjorie Robertson, English stage and film actress and singer
Denny Neagle (born 1968), former Major League Baseball pitcher
Jack Neagle (1858–1904), professional baseball pitcher in the major leagues from 1879 to 1884
James Neagle (1760–1822), British engraver
Jay Neagle (born 1988), Australian rules footballer formerly with the Essendon Football Club in the Australian Football League
John Neagle (1796–1865), fashionable American painter, primarily of portraits, in Philadelphia
Lamar Neagle (born 1987), American soccer player
Lynne Neagle AM (born 1968), Welsh Labour & Co-operative politician
Merv Neagle (1958–2012), Australian rules footballer who represented Essendon and Sydney in the Australian Football League
Monk & Neagle, American CCM duo from Amarillo, Texas, composed of Trent Monk and Michael Neagle
