Neagle is a surname. Notable people with the surname include:
Anna Neagle, DBE (1904–1986), born Florence Marjorie Robertson, English stage and film actress and singerDenny Neagle (born 1968), former Major League Baseball pitcherJack Neagle (1858–1904), professional baseball pitcher in the major leagues from 1879 to 1884James Neagle (1760–1822), British engraverJay Neagle (born 1988), Australian rules footballer formerly with the Essendon Football Club in the Australian Football LeagueJohn Neagle (1796–1865), fashionable American painter, primarily of portraits, in PhiladelphiaLamar Neagle (born 1987), American soccer playerLynne Neagle AM (born 1968), Welsh Labour & Co-operative politicianMerv Neagle (1958–2012), Australian rules footballer who represented Essendon and Sydney in the Australian Football LeagueMonk & Neagle, American CCM duo from Amarillo, Texas, composed of Trent Monk and Michael Neagle