National Register of Historic Places listings in Cherokee County, South Carolina

This is a list of the National Register of Historic Places listings in Cherokee County, South Carolina.

This is intended to be a complete list of the properties and districts on the National Register of Historic Places in Cherokee County, South Carolina, United States. The locations of National Register properties and districts for which the latitude and longitude coordinates are included below, may be seen in a map.

There are 25 properties and districts listed on the National Register in the county, including one located in both Cherokee County and Cleveland County, North Carolina. Another 4 properties and districts were once listed but have been removed.