National Register of Historic Places listings in Center City, Philadelphia

This is a list of the National Register of Historic Places listings in Center City, Philadelphia.

This is intended to be a complete list of the properties and districts on the National Register of Historic Places in Center City in Philadelphia, Pennsylvania, United States. The locations of National Register properties and districts for which the latitude and longitude coordinates are included below, may be seen in a Google map.

There are 558 properties and districts listed on the National Register in Philadelphia, including 67 National Historic Landmarks. Center City includes 145 of these properties and districts, including 34 National Historic Landmarks; the city's remaining properties and districts are listed elsewhere. Ten historic districts cover almost half of Center City including essentially all the area between the Schuylkill and Delaware Rivers from Chestnut Street on the north to Locust Street on the south. Five other properties in Center City were once listed but have been removed.