Napoli is an Italian surname. Notable people with the surname include:
Aiman Napoli (born 1989), Italian footballer
Alexander J. Napoli (1905–1972), a United States federal judge
Arturo Di Napoli (born 1974), Italian footballer
Donna Jo Napoli, author and professor of linguistics at Swarthmore College
Emanuele Napoli, painter mainly doing copies and a restorer at the Royal Palace of Capodimonte in the reign of Ferdinand IV.
Fernando De Napoli (born 1964), Italian footballer
Gennaro Di Napoli (born 1968), Italian middle distance runner
Jacopo Napoli (1911–1994), Italian composer
James Napoli (1911–1992), New York mobster in the Genovese crime family
Jeanne Napoli (1938–2010), American singer, songwriter, and performer
Mike Napoli (born 1981), Major League Baseball player with the Cleveland Indians.
Nicola Napoli (1905–1982), president of Artkino films
Nicolò Napoli (born 1962), Italian footballer
Patrick de Napoli (born 1975), Swiss footballer
Patrick Esposito Di Napoli (1964–1994), Canadian musician
Thomas DiNapoli (born 1954), American politician
Tommaso Napoli (1659–1725), Italian architect
William Napoli, state Senator in South Dakota, United States
